Molecular network interacting with NPM-ALK. A complex network of protein kinases, protein phosphatases, transcription factors, apoptosis and cell-cycle regulators, adaptor proteins, and other molecules has been proposed to interact with NPM-ALK. The association and interaction between NPM-ALK and the majority of these molecules have been documented and briefly discussed in this review article. This model provides a rationale for designing specific and selective therapeutics that can target, individually or synergistically, members of this network and disrupt their oncogenic effects.