Suppression of CD13 activity inhibits bradykinin-induced filopodia formation. (A) HUVECs were trypsinized and replated with bradykinin in the presence or absence of bestatin (100 μg/mL) or MY7 antibody (CD13 mAb, 1:100 dilution) and stained with filipin as in Figure 3. (B) Bestatin (100 μg/mL) inhibits bradykinin signal transduction, resulting in inhibition of Cdc42 but not Rac activation in HUVECs.