Structural elements and known binding partners of Dok-3. Dok-3 interacts with various signaling proteins via a PTB domain and several C-terminal phosphorylated (p) tyrosine (Y) residues. Known interactions are indicated by double-sided arrows. The pleckstrin homology (PH) domain can interact with phosphatidylinositol 3,4,5-trisphosphate (PIP3) at the plasma membrane.