Thymic output and T-cell proliferation. (A) and (B) Graphs show changes in the frequency of CD4+ and CD8+ T cells containing TREC before and after transplantation. (C) and (D) Graphs show the frequency of Ki67+ CD4+ and Ki67+ CD8+ T cells in blood before and after transplantation. (E) and (F) Graphs show the frequency of Ki67+ CD4+ and T CD8+ T cells in lymph node before and after transplantation. Animals given multiple doses of KGF are indicated with blue symbols, those given a single dose of KGF with green symbols, and control animals with red symbols. Data are displayed are as median and IQR. For the 2 animals receiving multiple doses, only median is plotted as an IQR would be statistically unreliable. Significant P indicated for comparisons between multiple-dose-KGF–treated or all KGF-treated animals and controls.