RBM6-CSF1R and truncated CSF1R induce a myeloproliferative disease in a murine bone marrow transplant model. (A) Kaplan-Meyer survival curves of C57/Bl6 transplant recipients. (B) Kaplan-Meyer survival curves of Balb/C transplant recipients. (C) Spleen weight at 150 days after transplantation. Mean ± SD is shown (for each group, n = 3). (D) Splenocytes were plated in methylcellulose cultures containing IL-3, IL-6, SCF, EPO, and myeloid colonies were scored after 7 days. Experiment was performed in triplicate and mean ± SD is shown. (E) Flow cytometric analysis of Balb/C recipients total splenocytes. Experiment was performed in duplicate and a representative experiment is shown. (F) Flow cytometric analysis of C57/Bl6 recipients total splenocytes. Experiment was performed in duplicate and a representative experiment is shown.