Figure 5
Figure 5. Competition by CXCL11 isoforms for radioactive ligand binding to lymphocytes or CXCR3- or CXCR7-transfected CHO cells. Increasing concentrations of unlabeled synthetic CXCL11(1-73) (■), CXCL11(3-73) (▴), CXCL11(5-73) (♦), CXCL11(7-73) (○), or recombinant CXCL12 (□) were added together with 125I-CXCL11 to CHO-CXCR3 cells (A), lymphocytes (B), or CHO-CXCR7 cells (C) or were incubated with CHO-CXCR7 cells in the presence of 125I-CXCL12 (D). Results represent the remaining mean (± SEM) percentage specific 125I-CXCL11 or 125I-CXCL12 binding for 3 to 7 independent experiments.

Competition by CXCL11 isoforms for radioactive ligand binding to lymphocytes or CXCR3- or CXCR7-transfected CHO cells. Increasing concentrations of unlabeled synthetic CXCL11(1-73) (■), CXCL11(3-73) (▴), CXCL11(5-73) (♦), CXCL11(7-73) (○), or recombinant CXCL12 (□) were added together with 125I-CXCL11 to CHO-CXCR3 cells (A), lymphocytes (B), or CHO-CXCR7 cells (C) or were incubated with CHO-CXCR7 cells in the presence of 125I-CXCL12 (D). Results represent the remaining mean (± SEM) percentage specific 125I-CXCL11 or 125I-CXCL12 binding for 3 to 7 independent experiments.

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