American Society of Hematology

Figure 6

$Figure 6. R18 induces apoptosis in part through FOXO3a in cells expressing ZNF198-FGFR1. (A) Cells were transfected with siRNA for 24 hours before Dox induction. The apoptotic population was characterized as the fraction of annexin V/YFP double-positive cells in total YFP-positive cells (%). Indicated P values were determined by the Student t test. (B) MEK1 inhibitor U0126 treatment enhanced R18-induced apoptosis in the 4ZF-transformed TonBaF cells. Cells were treated with an increasing concentration of Dox in the presence or absence of U0126 for 24 hours, followed by annexin V staining and FACS analysis for the apoptotic population.$

R18 induces apoptosis in part through FOXO3a in cells expressing ZNF198-FGFR1. (A) Cells were transfected with siRNA for 24 hours before Dox induction. The apoptotic population was characterized as the fraction of annexin V/YFP double-positive cells in total YFP-positive cells (%). Indicated P values were determined by the Student t test. (B) MEK1 inhibitor U0126 treatment enhanced R18-induced apoptosis in the 4ZF-transformed TonBaF cells. Cells were treated with an increasing concentration of Dox in the presence or absence of U0126 for 24 hours, followed by annexin V staining and FACS analysis for the apoptotic population.

This Feature Is Available To Subscribers Only