Fibrinogen is localized at vascular sinusoids in the bone marrow. Representative images from frozen murine femur sections costained with an FITC-conjugated anti-mouse fibrinogen antibody or an IgG control antibody together with a biotin-linked anti-CD105 antibody preincubated with Texas Red-linked streptavidin. The tissue sections were visualized via confocal microscopy. Note that while sinusoidal gaps are visible in the control stain, there is no enrichment of green staining around the periphery of the sinusoid. Results are representative of 4 separate experiments.