LOH at chromosome 17 loci in NF1-associated myeloid malignancies. Ideogram and schematic of chromosome 17 showing the loci that were screened for LOH. For each tumor, a bar shows the single chromosome 17 that underwent LOH with informative loci (tick marks), segments showing biparental inheritance (□), segments that underwent LOH (▪), segments where a recombination event occurred (), and qter segments that lacked informative loci (?). Below the schematic, the parental origin is given for the isodisomic and deleted regions for each tumor. For patients 1, 2, 3, and 8, the maternal homolog is shown with the region of paternal isodisomy indicated in black. For patients 4 through 7, the paternal homolog is shown with the region of maternal isodisomy indicated in black. LOH in patients 9 and 10 occurred by intrachromosomal deletion indicated in black. Additional chromosome 17 loci that were tested, but not informative, are not shown. Physical distances (rounded to the nearest tenth of a megabase) are based on the May 2004 assembly of the human genome (http://genome.uscs.edu), in which the length of chromosome 17 is given as 78 774 742 bp.