Graph demonstrating the significant difference in IUR between the low and high IC50^imatinib groups. (A) For imatinib, median IUR shown in parentheses. (B) Graph demonstrating the similarity in IUR for nilotinib, between the low and high IC50^nilotinib groups. Median IUR shown in parentheses. (C) Effect of the OCT-1 inhibitor prazosin on IUR for low and high IC50^imatinib groups. (D) Effect of the OCT-1 inhibitor prazosin on IUR for low and high IC50niltoinib groups. Error bars indicate one standard deviation (SD).