Cotreatment with LBH589 and AMN107 induces more apoptosis of BaF3/Bcr-Abl, BaF3/Bcr-AblT315I, and BaF3/Bcr-AblE255K cells. Cells were treated with the indicated concentrations of LBH589 and/or AMN107 for 48 hours, and the percentage of apoptotic cells was determined by annexin V staining followed by flow cytometry. Values (mean ± SEM of 3 experiments performed in duplicate) are depicted as bars.