AMN107 and LBH589 induce apoptosis of K562 and LAMA-84 cells. Cells were treated with the indicated concentrations of AMN107 or IM (A) or LBH589 (B) for 48 hours. Following this, the percentage of annexin V–stained apoptotic cells was determined by flow cytometry. Values represented as bar graphs are mean of 3 experiments ± SEM.