Figure 4.
Elastase release from neutrophils with different FcγRIIa/FcγRIIb2 mRNA ratios upon stimulation with polymeric IgG. (A) Elastase release from neutrophils with different FcγRIIa/FcγRIIb2 ratios, obtained from several individuals selected from the white population, was measured after stimulation with 50 μg/mL dimeric IgG. The difference between the 3 groups tested was significant. (B) Whole blood, obtained from several individuals selected from the white population, was stimulated with either 50 μg/mL dimeric IgG in the presence or absence of blocking Fab anti-FcγRII and/or blocking F(ab′)2 anti-FcγRIII or fMLP supplemented with cytochalasin B, and elastase release was measured. Error bars represent SEM.
