SHIP downregulates FcγR-induced production of IL-1β and IL-6. BMMs obtained from SHIP^+/+ and SHIP^–/– mice were stimulated for the time points indicated in the figure with heat-aggregated IgG. (A) The levels of IL-1β and (B) IL-6 in lysates and supernatants were measured by ELISA. The graphs represent the mean and SEM of values obtained from 3 independent experiments. Data were analyzed by Student t test (*P ≤ .05).