The influence of the angiotensin receptor 2 on thrombosis risk. (A) BKB2R^-/- mice and their controls (B6129SF2/J) were treated with 30 mg/kg per day PD123 319 or saline by a subcutaneous osmotic pump for 7 days. After the treatment period, the time to vessel occlusion was determined using the Rose Bengal model for mouse carotid artery thrombosis. The data presented are the mean plus or minus SEM of 5 or more experiments with mice simultaneously treated with each of the conditions shown. (B) BKB2R^-/- mice and their controls were treated with 0.5 mg/mL L-NAME and 50 μg/mL nimesulide (L/N treatment) added daily to fresh drinking water for 10 days. After the treatment period, the tail bleeding time was determined. The data presented are the mean plus or minus SEM of 5 experiments with mice simultaneously treated with each of the conditions shown.