Figure 2.
Summary of IL-7Rα and IL-15Rα expression on EBV-specific CD8+ T cells in acute IM and post-IM patients versus healthy carriers. Scatterplots of IL-7Rα expression or IL-15Rα on EBV lytic epitope-specific CD8+ T cells (top panels) and on EBV latent epitope-specific CD8+ cells (bottom panels). Results are expressed as the percentage of tetramer-positive cells that are IL-7Rα (left panels) or IL-15Rα (right panels) positive, and each individual symbol shows the value for a particular epitope in a particular donor tested within a particular time interval after infection (ie, in acute IM, 1-18 months after IM, and 2-14 years after IM). Results for equivalent EBV epitope-specific memory cells in healthy EBV carriers are also shown (gray area). Horizontal lines represent the median value for each specificity/time-point combination. Statistical analysis was performed using the Mann-Whitney test; significant differences are indicated by asterisks (*P < .001).

Summary of IL-7Rα and IL-15Rα expression on EBV-specific CD8+ T cells in acute IM and post-IM patients versus healthy carriers. Scatterplots of IL-7Rα expression or IL-15Rα on EBV lytic epitope-specific CD8+ T cells (top panels) and on EBV latent epitope-specific CD8+ cells (bottom panels). Results are expressed as the percentage of tetramer-positive cells that are IL-7Rα (left panels) or IL-15Rα (right panels) positive, and each individual symbol shows the value for a particular epitope in a particular donor tested within a particular time interval after infection (ie, in acute IM, 1-18 months after IM, and 2-14 years after IM). Results for equivalent EBV epitope-specific memory cells in healthy EBV carriers are also shown (gray area). Horizontal lines represent the median value for each specificity/time-point combination. Statistical analysis was performed using the Mann-Whitney test; significant differences are indicated by asterisks (*P < .001).

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