Individual profiles of PrPd accumulation in the brains of BSE donor and recipient sheep. Relationship between donors (D; open symbols) and recipients (R; filled symbols), indicating points of birth (triangles), infection (diamonds), appearance of clinical signs (circles), and necropsy (squares); numbers indicate days. Donors and recipients in italics are not considered in the estimation of incubation periods or in the average PrPd profiles of Figure 2. Note that BD4 did not show signs of TSE at the time of death, and that BD1 and BD2 donated blood when clinically affected, while all the other donors were preclinical at that time. PrPd types are as follows: ITNR indicates intraneuronal; ITAS, intrastrocytic; ITMG, intramicroglial; STEL, stellate; SBPL, subpial; SBEP, subependymal; PRVS, perivascular; PVAC, perivacuolar; PRCO, particulate-coalescing; LINR, linear; PNER, perineuronal; EPEN, ependymal; and VASC, vascular plaques. Note that BR3 and BR4 have been referred to previously as D505 and F19, respectively.6,7
