Lack of correlation between magnitude or breadth of SIV-specific T-cell responses and CD4⁺ T-cell counts in naturally SIV-infected SMs. (A-B) The percent of SIV-specific CD3⁺CD8⁺ T cells (A) or CD3⁺CD8^- T cells (B) was plotted along with CD4⁺ T-cell counts (cells/mm3). Magnitude of the SIV-specific response is represented by the percent of CD3⁺CD8⁺ or CD3⁺CD8^- T cells producing either IFN-γ or TNF-α in response to SIVmac239 peptide pools. P = ns indicates that the P value of the correlation coefficient is more than .05 (Spearman rank correlation test).