Lack of correlation between magnitude or breadth of SIV-specific T-cell responses and viral load in naturally SIV-infected SMs. (A-B) The percent of SIV-specific CD3⁺CD8⁺ T cells (A) or CD3⁺CD8^- T cells (B) was plotted along with SIV viremia (copies/mL plasma). Magnitude of the SIV-specific response is represented by the percent of CD3⁺CD8⁺ or CD3⁺CD8^- T cells producing either IFN-γ or TNF-α in response to SIVmac239 peptide pools. P = ns indicates that the P value of the correlation coefficient is more than .05 (Spearman rank correlation test). (C-D) Comparison of viral load (copies/mL plasma) in naturally SIV-infected SMs grouped by the presence of detectable CD3⁺CD8⁺ (C) or CD3⁺CD8^- (D) T-cell-mediated responses to 4, 3, 2, 1, or no SIVmac239 antigens. One-way nonparametric ANOVA (Kruskal-Wallis) followed by Dunn multiple comparison test found no significant differences between the groups. Horizontal lines indicate mean values.