GVT response is maintained in the presence of DC_VIPs. GVHD was induced in recipient Balb/c (H-2^d) mice by allogeneic transplantation of BMS from B6 (H-2^b) mice. GVT effect was induced by injecting A20 leukemic (H-2^d) cells (A) or P815 mastocytoma (H-2^d) cells (B) into recipient mice at time of BMS transplantation. Recipients were treated with DC_controls (○) or DC_VIPs (▾) obtained from Balb/c (H-2^d) mice at time of transplantation. Mice given injections of A20 or P815 cells alone were used as controls (none, •). Recipients were monitored for survival and body weight. Liver and spleen weights were determined from representative recipients at time of death or 60 days after transplantation (dotted vertical lines correspond to spleen and liver weights of normal Balb/c mice). Leukemia growth/elimination was assessed by the presence of A20 cells in blood detected by coexpression of B220 and H-2K^d and by size (5-10 mice/group). ^*P < .01 versus untreated recipients. P < .01 versus DC_VIPs group.