Figure 4.
Figure 4. Genomic structure and gene/protein alignment of human PANE1 transcripts. (A) PANE1 transcripts k and c share a common last exon. The first exon of transcript k is unique from all other PANE1 transcripts, and the sequence encoding the CTL-7A7 mHAg RVWDLPGVLK is contained entirely within this first exon, as indicated by the vertical arrow. (B) PANE1 transcript k nucleotide sequence, and sequence of its predicted 58-amino acid isoform. The polymorphic nucleotide generating the CTL-7A7 mHAg is indicated by a vertical arrow. These sequence data are available from Entrez PubMed (http://www.ncbi.nlm.nih.gov/entrez) under accession number BQ056829. Italicized nucleotides represent additional 5′ and 3′ sequence determined by RACE PCR. (C) Comparison of the predicted protein sequences of PANE1 isoforms k and c. Asterisks indicate amino acid identity; bold type indicates CTL-7A7 epitope, with polymorphic residue indicated by an arrow.

Genomic structure and gene/protein alignment of human PANE1 transcripts. (A) PANE1 transcripts k and c share a common last exon. The first exon of transcript k is unique from all other PANE1 transcripts, and the sequence encoding the CTL-7A7 mHAg RVWDLPGVLK is contained entirely within this first exon, as indicated by the vertical arrow. (B) PANE1 transcript k nucleotide sequence, and sequence of its predicted 58-amino acid isoform. The polymorphic nucleotide generating the CTL-7A7 mHAg is indicated by a vertical arrow. These sequence data are available from Entrez PubMed (http://www.ncbi.nlm.nih.gov/entrez) under accession number BQ056829. Italicized nucleotides represent additional 5′ and 3′ sequence determined by RACE PCR. (C) Comparison of the predicted protein sequences of PANE1 isoforms k and c. Asterisks indicate amino acid identity; bold type indicates CTL-7A7 epitope, with polymorphic residue indicated by an arrow.

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