Induction of NF-κB, STAT1, and p53 activation in latency III–induced EREB2-5 cells. (A) NF-κB binding activity in estrogen-deprived (-) or estrogen-treated (+) EREB2-5 cells and in LCL cells by EMSA. (B) Kinetics of p53 protein expression, serine 15 p53 phosphorylation, STAT1 protein expression, and tyrosine 701 STAT1 phosphorylation in EREB2-5 cells. 0h indicates estrogen-deprived; 3h, 8h, 24h, and cont indicate 3, 8, and 24 hours, and continuous estrogen exposition, respectively.