Decreases of BFUs of bone marrow blasts from BC CML patient samples by survivin down-regulation. Expression of survivin in bone marrow samples of blast crisis CML, Ph⁺ cell lines, and normal CD34⁺ cells by Western blot (A). Survivin expression (48 hours) by Western blot and CFUs of CML bone marrow (n = 5) (B) and normal bone marrow (n = 3) (C) treated with Sur-AS-ODN. Sol cont indicates solution T control; prog cont, nucleofection program K17 control; NS, Sur-NS-ODN control; AS, Sur-AS-ODN.