The TMDR contains a p53RE evolutionarily conserved in primates. (A) Schematic representation of the human BCL6 gene. Coding and noncoding exons are indicated by ▪ and □, respectively. MTC indicates major translocation cluster; MMC, major mutation cluster; Del overlap, region of internal deletions overlap; BP-HCR, breakpoint hyper-cluster region; TMDR, translocations, mutations, and deletions region; and the bar above the BCL6 gene, fragment cloned for the luciferase assay. (B) Sequence of a segment of the human BCL6 intron 1 containing a p53RE. The nucleotides are numbered relative to the transcription start site. The 2 decamers of the p53RE are in bold; the TMDR is between brackets; the BP-HCR is underlined; the region of deletions overlap is between parentheses; the primers used for the BCL6 ChIP analysis are italicized. (C) Reported translocations and mutations in the BCL6 p53RE. Arrowheads indicate positions of breakpoints of translocations; •, point mutations; □, each row represents the point mutations of a single patient with at least 3 mutations in the p53RE; Ref, reference; Diagn, diagnosis; DLBCL, diffuse large B-cell lymphoma; BL, Burkitt lymphoma; and —, not available. The WRCY motif (tgct) is underlined with a solid line; the 12-bp spacer is underlined with a dashed line; the details of the patients appear in the left table, along with the case no. from the original article.