Design of first-generation MIP-1α/RANTES chimeras. (A) Alignment of the primary sequences of murine (mu) and human (h) MIP-1α and RANTES; the limits of the structural domains are shown above the sequence. L indicates loop; T, turn; and β, beta sheet. Subdivision of the sequences into N (1), C (3), and internal (2) sections is shown below the sequences. (B) Design of first-generation MIP-1α/RANTES chimeras: muMIP-1α sequences (MMM) are represented by bold lines and hRANTES sequences (RRR) by dotted lines. The conserved cysteine residues are represented by the letter C.