Figure 7.
Migration of RS-MSCs and SR-MSCs. (A) Migration of RS-MSCs and SR-MSCs induced by SDF-1 and fractalkine. The bottom wells contained either 20% fetal calf serum, serum-free medium, 50 ng/mL SDF-1, 50 ng/mL SDF-1 plus 10 μg/mL anti-CXCR4, 10 ng/mL fractalkine, or 10 ng/mL fractaline plus 5 μg/mL anti-CX3CR1. Migration was assayed by photomicrograph of the underside of the opaque inserts (magnification, × 200). Data are expressed as mean and range of 2 values. (B) Migration of RS-MSCs and SR-MSCs to neurospheres. Assays and values as in panelA, except SDF-1 and fractalkine were replaced with about 1 × 105 neural stem cells from neurospheres. Data are expressed as mean and range of 2 values.
