Ideogram illustration of dynamic changes underlying imatinib mesylate/ATO-induced apoptosis in CML. Genes modulated in the imatinib mesylate series are marked in red (up-regulation) and blue (down-regulation), whereas those modulated in the ATO series are framed by red (up-regulation) and blue (down-regulation), and those modulated in the cotreatment series are highlighted by pink (up-regulation) and light-blue (down-regulation) background. ^*Synergistically/additively affected genes in the cotreatment series. Unchanged genes are indicated in black-framed boxes. Molecular events at the early, intermediate, and late stages are rimmed, respectively, by yellow, pink, and red lines.