Changes in proportions of PNH-type granulocytes associated with responses to IST. (A) Change in responders and nonresponders. (B) Proportions of granulocyte counts after and before IST determined for PNH-type (a) and normal-type (b) granulocytes and ratios of PNH-type granulocytes (a) to normal-type granulocytes (b) were plotted. (C) Longitudinal analysis of PNH-type granulocytes. Proportions of PNH-type granulocytes of 37 patients with PNH⁺ and 1 patient with PNH^- who became PNH⁺ (black line) were displayed. (D) Changes in proportions of PNH-type granulocytes over 5 years in patient UPN 106 with AA (shown as D in Figure 5C).