Figure 7.
![Figure 7. Immunohistochemical detection of SHP1 phosphatase using tissue microarrays (TMAs). (Left) ALCL positive for SHP1 protein showing a strong diffuse cytoplasmic staining. (Middle) Case showing heterogeneous SHP1 expression, some strongly positive cells among negative cells (arrows). (Right) ALCL negative for SHP1; only reactive lymphocytes admixed with lymphoma cells are positive for SHP1 and used as an internal control. All these cases are ALK-positive ALCLs (original magnifications ×8 [top] and ×50 [bottom]).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/107/10/10.1182_blood-2005-06-2421/2/zh80100695400007.jpeg?Expires=1724247663&Signature=2b0ZwEy~M36rIjJ9WyqbK9RjqP5hJa5Zy751QmDC4T2hbDH2ZzOst43SxyFYHX4z7o-8il58durn~nFc5t8eOtGa-Ch7P8q2NnPKbTEIpydr-LGta4fZ3QllCa8FC~OltTP83pztX-yzi6EAwNYeBI~AbynBWt3rgARLxbWQmylXZ5~uFOTro3eoeCTLJa0F-dSKrzDQMfb5U-lqhmzI~iPtY5Yp6S-11WRlJ1OHEHRzo3LiSudYwfiNEK5JgUFz1ztdbYbAxa37aJ9UbSUptz7LiPuq~w1tt3FLOwmP9gHaWVzd-4mpB59U8-ANs1HTK4IXjf6Jd6MtvFzkCzs32A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Immunohistochemical detection of SHP1 phosphatase using tissue microarrays (TMAs). (Left) ALCL positive for SHP1 protein showing a strong diffuse cytoplasmic staining. (Middle) Case showing heterogeneous SHP1 expression, some strongly positive cells among negative cells (arrows). (Right) ALCL negative for SHP1; only reactive lymphocytes admixed with lymphoma cells are positive for SHP1 and used as an internal control. All these cases are ALK-positive ALCLs (original magnifications ×8 [top] and ×50 [bottom]).
