Comparison between the murine eosinophilic disease model induced by the F/P fusion gene and the BCR/ABL-induced disorder under conditions of IL-5 overexpression. Mice that received a transplant of non-Tg, F/P-transduced (non–Tg-F/P); IL-5 Tg, F/P-transduced (IL-5Tg-F/P); non-Tg, p210-BCR/ABL–transduced (non–Tg-BCR/ABL); and IL-5 Tg, p210-BCR/ABL–transduced (IL-5Tg-BCR/ABL) HSCs/Ps were analyzed just after disease development. Total eosinophil counts using Discombe staining (A) and frequency of CCR3⁺CD11b⁺/low cells in EGFP⁺/7AAD^– or EGFP^–/7AAD^– by flow cytometer (B) were measured when the mice fully developed diseases. The eosinophil count in all samples was divided by the average of those of IL-5Tg-mock recipients in each experiment for standardization. Data represent 6 to 10 mice per group, pooled from 2 or 3 independent experiments. Data in panel A are shown as mean ± SD. (C) Representative example (of 3-5 mice per group, pooled from 1 or 2 independent experiments) of expression of IL-5 receptor α on EGFP^– and EGFP⁺ splenocytes in IL-5Tg-mock (blue line), IL-5Tg-F/P (red line), and IL-5Tg-BCR-ABL (green line) as analyzed by flow cytometry is shown.