Coadministration of PS-341 and 153-Sm-EDTMP prolongs the median survival time of 5TGM1-bearing mice. Kaplan-Meier survival plot of mice (n = 8 per group) with established murine multiple myeloma after intraperitoneal administration of PBS (▪; day 14 and 16), PS-341 (▾; day 14 and 16), 153-Sm-EDTMP (•; day 15), or PS-341/153-Sm-EDTMP/PS-341 (□; day 14/15/16). Data end for each group once mice succumb to disease and meet criteria for killing.