OS, DFS, and CIR in AML patients (60 years or younger) with normal karyotype. (A) Comparison of the probability of OS according to the NPM1 and FLT3-ITD mutational status in the 4 defined groups. Group A (NPM1-mut alone) had a significantly higher actuarial probability of OS than group B (double mutants; P = .003) and D (all wt; P = .02), and trend was seen versus group C (FLT3-ITD alone; P = .11). (B) Probability of DFS in the 4 groups. Group A had a significantly higher probability of disease-free survival than group B (P = .02), group C (P < .001), and group D (P = .006). (C) CIR in the 4 groups. Analysis was done using the Gray k-sample algorithm in patients with normal karyotype showing a significantly reduced CIR for group A (CIR at 40 months, 25%) compared with the other groups (P = .004). Highest relapse rates were seen in group B (57%) and group C (51%); the CIR was 32.7% in group D.