Kaplan-Meier analysis of NPM1 and FLT3-ITD mutations in patients with AML and normal karyotype. Kaplan-Meier analysis of OS (A) and DFS (B) in AML patients with normal karyotype according to NPM1 mutations; OS (C) and DFS (D) according to NPM1 and FLT3-ITD groups. Analysis was done in the 4 groups defined in the text. Patients in group A (NPM1-mut alone) had a significantly higher probability of OS than group B (double mutants; P = .001), group C (FLT3-ITD^pos only; P = .032), and group D (wt for both; P = .03). Also, the DFS was significantly higher in group A than group B (P = .04), group C (P < .001), and group D (P = .04).