Mutations of NPM1 found in 229 sequenced patients. Comparison of the nucleotide and deduced amino acid sequences of mutations identified in AML patients. Amino acids are given in single-letter code. The blue boxes denote the 2 tryptophan residues at amino acid positions 288 and 290 important for nuclear transport.³⁴  (A) Mutations described by Falini et al.¹⁵  (B) Novel mutations. *Also described by Suzuki et al.³⁵