Serial analysis of CGAg-specific CD8⁺ T-cell responses in 11 patients with multiple myeloma. The x-axis indicates the number of months from diagnosis, the dashed line represents paraprotein level, and the black line represents CD8⁺ T-cell response to CGAg peptide from the point of analysis. (A) Four patients (21, 11, 4, and 7) were at a plateau stage of disease. (B) Seven patients (13, 22, 20, 30, 17, and 27) illustrated changing tumor burden. Treatment regimens are shown. Thal indicates thalidomide; CVAMP, cyclophosphamide, vincristine, Adriamycin, methylprednisolone, and prednisolone; PBSCT, peripheral blood stem cell transplant; Melph, melphalan; Dex, dexamethasone; VAD, vincristine, doxorubicin, dexamethasone; CDT; cyclophosphamide, dexamethasone, thalidomide.