Effect of NS-187 on in vivo tumor growth. (A) Balb/c-nu/nu mice received subcutaneous transplants of KU812 cells (day 0) and were given vehicle (•), NS-187 (▵, 0.2 mg/kg/d; ▴, 20 mg/kg/d), or imatinib (□, 20 mg/kg/d; ▪, 200 mg/kg/d) daily from day 7 to day 17. Data points represent the mean ± standard deviation calculated for 7 mice. Effect of NS-187 in BaF3-leukemia model. (B) Survival of Balb/c-nu/nu mice that received transplants of BaF3/wt cells and given vehicle (black), NS-187 (pink, 6 mg/kg/d; yellow, 20 mg/kg/d; green, 60 mg/kg/d; purple, 120 mg/kg/d; red, 200 mg/kg/d), or imatinib (blue; 400 mg/kg/d) daily from day 1 to day 11. (C) Survival of Balb/c-nu/nu mice that received transplants of BaF3/E255K cells and given vehicle (black), NS-187 (red; 120 mg/kg/d), or imatinib (blue; 200 mg/kg/d) daily from day 1 to day 26. ^*P < .05; ^**P < .01.