Kinase inhibition profile and the docking model. (A-B) Kinase inhibition profile of NS-187 and Abl (panel B is the continuation of panel A). Seventy-nine tyrosine kinases, including 5 Src-family kinases (Blk, Src, Fyn, Lyn, and Yes; indicated by Δ on the x-axis) were assayed by KinaseProfiler. At 0.1 μM, NS-187 inhibited 4 of the 79 tyrosine kinases, namely, Abl, Arg, Fyn, and Lyn (indicated by red on the x-axis). (C) Close view of the docking model of NS-187 and Abl. Hydrogen-bonding interactions are shown as white broken lines. Movement of the P-loop shown in pink and the hydrogen-bonding interactions of the amino acids shown in sky blue contribute to stabilize the complex.