BM9 or BM10 expression promotes loss of KSHV plasmid in CM12 during transient transfection. Gardella gel electrophoresis followed by Southern blot hybridization with a TR probe shows loss of viral genome from CM12 cells stably transfected with KSHV-BAC36 GFP and transiently transfected with BM9 and BM10. Transfection with the negative control 4BL intrabody has no effect on viral persistence.