Kaplan-Meier analysis of AML with normal karyotype and different NPM1 and FLT3-TKD status. The prognostically favorable impact of NPM1 mutations was overcome by an additional FLT3-LM. (A) OS. (B) EFS. Blue lines indicate NPM1^–/FLT3TKD^– (n=153); green lines, NPM1⁺/FLT3TKD^– (n=192); black lines, NPM1^–/FLT3TKD⁺ (n=6); and red lines, NPM1⁺/FLT3TKD⁺ (n=20). Results were significant at a level of P < .05 at both sides.