Kaplan-Meier analysis of AML with normal karyotype and different NPM1 and FLT3-LM status. The prognostically favorable impact of NPM1 mutations was overcome by an additional FLT3-LM. (A) OS. (B) EFS. (C) RFS. Blue lines indicate NPM1^–/FLT3-LM^–; green lines, NPM1⁺/FLT3-LM^–; black lines, NPM1^–/FLT3-LM⁺; and red lines, NPM1⁺/FLT3-LM⁺. Results were significant at a level of P < .05 at both sides.