The most predictive molecular signature with regard to NPM1 mutation in AML assessed with 22 probe sets representing 18 unique genes. The levels of expression of the probe sets in the 275 cases of AML are depicted (scale bar indicates an increase [red] or a decrease [green] in the level of expression of at least 4 relative to the geometric mean).²¹  The 3 probe sets representing the NPM1 gene are also depicted.