Statistically significant changes in RBC and plasma features across transfusion time. (A) Complete blood count. (B) Fluctuations in RBC characteristics and plasma antioxidants. (C) Changes in hepcidin and coagulation/endothelium status markers. Repeated measures ANOVA with post hoc comparisons. ∗P < .05 vs before; #P < .05 vs after. Shaded area: control range in healthy participants (average ± standard deviation).25 aPTT, activated partial thromboplastin time; AT-III, antithrombin- III activity; Ctrl, control; EOS, eosinophil; MCHC, mean corpuscular Hb concentration; MFI, mechanical fragility index; PPAm, proteolytic proteasome activity at the RBC membrane; RPR, the ratio of red cell distribution width to platelets; TAC, total antioxidant capacity of plasma.
