Chord diagram shows the cross-linking profile of in vitro fibrin clots formed with FXIIIA and TG2. (A) Cross-linking pattern of FIB1 with copurified FXIIIA. Schematic representation of the FGG (red), FGB (orange), and FGA Q sites (yellow to green) found in cross-links (starting at the top of the circle and moving clockwise). Schematic representation of the FGG and FGA N- to C-terminal K sites (light blue to pink) (from the bottom clockwise to top). The length of the outer arc is kept constant and is based on the maximum number of cross-links observed at that site across conditions. The chord widths are based on the number of cross-links. (B) Cross-linking pattern of FIB with copurified FXIIIA and human TG2. (C) Cross-linking pattern of FXIIIA-free FIB (peak 1) with human TG2.