Clinical PBMC biomarker analysis. (A) Plot of CD8⁺CD4⁻ T-cell populations by treatment arm and visit. (B) Plot of CD4⁺CD8⁻ T-cell populations by treatment arm and visit. Only visits through month 12 are presented. Day −1 visits were used as baseline except for patients with missing day −1 assessments (n = 2). For these 2 patients, the most recent pretreatment unscheduled visit was used as baseline. BL, baseline; CM, central memory; EM, effector memory; N/T_scm, naive/stem cell memory T cell; PBMC, peripheral blood mononuclear cell.