Figure 1. Elevated pcVWF levels in... | American Society of Hematology

Figure 1.

$Elevated pcVWF levels in patients with acute iTTP. (A) VWF:Ag levels and (B) pcVWF levels were measured using ELISA in healthy donors (n = 43) and patients with acute iTTP (n = 83). (C) pcVWF levels were divided by VWF:Ag to determine the fraction of pcVWF relative to total VWF:Ag. Graphs show individual values with medians. Normality was assessed using the Shapiro-Wilk, D’Agostino and Pearson, and Anderson-Darling tests. Group comparisons were performed using the Mann-Whitney test. ∗∗∗∗P < .0001. (D) VWF:Ag levels plotted against pcVWF levels for each patient. (E) LDH levels from routine hospital testing were plotted against pcVWF. Spearman rank correlation coefficient (r) was used to evaluate the correlations in panels D-E. LDH, lactate dehydrogenase.$

Elevated pcVWF levels in patients with acute iTTP. (A) VWF:Ag levels and (B) pcVWF levels were measured using ELISA in healthy donors (n = 43) and patients with acute iTTP (n = 83). (C) pcVWF levels were divided by VWF:Ag to determine the fraction of pcVWF relative to total VWF:Ag. Graphs show individual values with medians. Normality was assessed using the Shapiro-Wilk, D’Agostino and Pearson, and Anderson-Darling tests. Group comparisons were performed using the Mann-Whitney test. ∗∗∗∗P < .0001. (D) VWF:Ag levels plotted against pcVWF levels for each patient. (E) LDH levels from routine hospital testing were plotted against pcVWF. Spearman rank correlation coefficient (r) was used to evaluate the correlations in panels D-E. LDH, lactate dehydrogenase.

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