Figure 5.
Effect of MSC-derived S100A8 deletion on 5-FU and IR stress hematopoiesis. (A) Construction of the 5-FU and IR stress model. (B) A representative flow pattern of HSPC in BM. (C) Proportion of BM HSC in the S100A8-deficient and control groups 14 days after 5-FU and IR treatment (n = 6-7). (D) The proportion of BM hematopoietic progenitors in the S100A8-deficient and control groups 14 days after 5-FU and IR treatment (n = 6-7). (E) The percentage of BM mature lineage cells in the S100A8-deficient and control groups 14 days after 5-FU and IR (n = 6-7). (F) Proportion of PB mature lineage cells in the S100A8-deficient and control groups 14 days after 5-FU and IR treatment (n = 6-7). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001. Ctrl, control; i.p., intraperitoneal; KO, knockout.

Effect of MSC-derived S100A8 deletion on 5-FU and IR stress hematopoiesis. (A) Construction of the 5-FU and IR stress model. (B) A representative flow pattern of HSPC in BM. (C) Proportion of BM HSC in the S100A8-deficient and control groups 14 days after 5-FU and IR treatment (n = 6-7). (D) The proportion of BM hematopoietic progenitors in the S100A8-deficient and control groups 14 days after 5-FU and IR treatment (n = 6-7). (E) The percentage of BM mature lineage cells in the S100A8-deficient and control groups 14 days after 5-FU and IR (n = 6-7). (F) Proportion of PB mature lineage cells in the S100A8-deficient and control groups 14 days after 5-FU and IR treatment (n = 6-7). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001. Ctrl, control; i.p., intraperitoneal; KO, knockout.

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