Changes in PedsQL scores from baseline in adolescents in the primary efficacy set after exa-cel infusion. (A) Change from baseline in PedsQL physical, psychosocial, and total scores at month 12 and month 24 after exa-cel infusion. (B) Change from baseline in PedsQL psychosocial domain emotional, social, and school functioning subscores at month 12 and month 24 after exa-cel infusion. Dotted lines indicate the MCIDs for each measure. Baseline is defined as the most recent nonmissing measurement (scheduled or unscheduled) collected before the start of mobilization. SE, standard error.