Survival outcomes in pediatric patients with T-ALL based on risk by key gene alterations and clinical variables. (A) Multivariate Cox proportional hazards analysis for EFS incorporating USP7 SNVs, alterations in the model genes of Simonin et al, and clinical variables. (B) Multivariate Cox proportional hazards analysis for DFS. (C) Kaplan-Meier survival curve for EFS comparing risk groups by statistically significant variables in Cox analyses: CNS3 status, MRD, and USP7 SNVs. (D) Kaplan-Meier survival curve for DFS.