Representative images depicting progression of SCI burden between V1 and visit 2 V2, with brain MRI completed 12 months apart. At V1, axial fluid-attenuated inversion recovery (FLAIR) images show several punctate foci of hyperintensity in the centrum semiovale (block arrows). At V2, there is interval development of multifocal chronic cortical infarcts; for example, in the right occipital, right and left parietal lobes, and right middle frontal gyrus (arrows), as well as an ischemic focus in the left caudate head (arrowhead). In addition, multifocal FLAIR hyperintense white matter lesions in the centrum semiovale bilaterally have increased in number and conspicuity (block arrows). V1, visit 1; V2, visit 2.