Pathological changes in the femurs of HbSC and HbSS mice. (A) DXA analysis for BMD of femurs from 4-month-old cohort. (B) μCT analysis of femurs from the 4- and 12-month-old cohorts for trabecular BV/TV. (C) μCT analysis of femurs from the 4- and 12-month-old cohorts for cortical wall thickness (4-month-old cohort [HbAA, n = 4; HbSC, n = 4; HbSS, n = 3]; 12-month-old cohort [HbAA, n = 6; HbSC, n = 4; HbSS, n = 4]). Comparisons to HbAA mice are indicated in black; comparisons between HbSC and HbSS mice are indicated in blue. Data are presented as mean ± standard deviation; ∗P < .05; ∗∗P < .01. ns, no significant difference.